Benzodiazepine/ GABAA receptor characteristics
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biology
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published 04/08/2008
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SummaryGABAA (γ-aminobutyric acidA) receptors are recognized as the chief inhibitory neurotransmitter receptors in the mammalian central nervous system. The GABAA receptors are pentameric membrane proteins consisting of five subunits. The subunits can combine in different ways to form GABAA receptors, but the α1β2γ2 receptor subtype is found in most brain areas. The GABAA receptor is a membrane-spanning receptor that changes conformation when bound to GABA. This conformational change allows Cl− ions to pass down an electrochemical gradient, causing hyperpolarization of the neuron. The subunits can combine in different ways to form GABAA receptors, but the α1β2γ2 receptor subtype is found in most brain areas
Table of Contents
- Introduction.
- Methods.
- Tissue preparation.
- BZ saturation binding.
- Displacement experiment.
- Mutant Mouse Binding.
- PCR and gel electrophoresis.
- Results.
- Saturation analysis of 3H-Flu binding.
- Displacement experiment.
- Mutant mouse binding.
- Discussion.
- Displacement study.
- Mutant mouse binding.
- Conclusion.
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