Crohn’s Disease
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date published 23/10/2007
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SummaryCrohn’s Disease is a form of ileitis, or inflammation of the ileum, which is the terminal portion of the small intestine. It is characterized by abdominal pain, ulceration, and fibrous tissue buildup in the terminal portion of the ileum. This is a relatively new disease, with proper medical diagnoses dating back only to the 1960s. Although Crohn, Ginzberg, and Oppenheimer described it in 1932 as a chronic, low grade inflammation of the terminal ileum, in 1960 it was recognized that the same disorder affected the colon and had been confused with ulcerative colitis. So, Crohn’s disease is newly recognized, with a defined clinical and pathological description dating back only to the 1960s (Chiodini, 1989).
Table of Contents- Inflammatory T cell action in Crohn's disease suggests that inherited variations in the major histocompatibility complex class II genes may be of pathogenetic importance in inflammatory bowel disease.
- The diagnosis of ulcerative colitis and Crohn's disease was documents in 82 patients seen at the Center for the Study of Inflammatory Bowel Disease by endoscopic, histological, and clinical criteria
- Two different types of Crohn's disease are known as perforating and nonperforating.
- In non-perforating Crohn's Disease, IL-1 beta mRNA is uniquely up-regulated.
- The experiment involved 349 patients with Crohn's disease, 87 Crohn's disease affected relatives, 333 inflammatory bowel disease free relatives, 58 spouses, and 190 healthy control patients
- Results of this study showed that expression of the anti-mannan marker antibody is a familial trait in families of patients with Crohn's disease.
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